Alpha-Lipoic Acid (ALA) also known as Lipoic acid or Thioctic acid, is an antioxidant – a substance that prevents cell damage caused by compounds called free radicals in a process called oxidative stress. High level of blood glucose is one cause of oxidative stress. Intravenous and oral Alpha Lipoic Acid used for the treatment of diabetic neuropathy.
More than 20% of diabetic patients develop peripheral neuropathy, a type of nerve damage that may result in pain, loss of sensation and weakness, particularly in the lower extremities. In addition to the pain and disability caused by diabetic neuropathy, it is a leading cause of lower limb amputation in diabetic patients. A meta-analysis that combined the results of four randomized controlled trials, found that treatment with 600 mg/ day of intravenous racemic Lipoic acid for 3 weeks significantly reduced the symptoms of diabetic neuropathy to a clinically meaningful degree.
Chromium also called Glucose Tolerance Factor (GTF), is a nutrient that plays a vital role in enhancing the action of insulin produced in the body. Biologically active form of chromium participates in glucose metabolism by enhancing the effects of insulin. Because chromium appears to enhance the action of insulin and chromium deficiency has resulted in impaired glucose tolerance, chromium insufficiency has been hypothesized to be contributing factor to the development of Type 2. It  is thought  to  improve  blood  sugar status in diabetic patients by functioning as a co-factor for insulin.
Zinc is an essential mineral to the body, plays the important roles in growth and development, the immune response, neurological function. Nearly 100 different enzymes depend on zinc for their ability to catalyze vital chemical reactions.

PHARMACOLOGY:

Alpha Lipoic Acid: Reduces Neuropathy symptoms like pain, paresthesia and numbness. Alpha Lipoic Acid (ALA) is a powerful natural antioxidant. It has been used to improve diabetic neuropathies and has reduced pain in several studies. Supplementing with Alpha Lipoic Acid for six months has been found to reverse the cause of diabetic nerve damage and improve this painful condition. Chromium supplementation enhances the sensitivity of insulin receptors in the body. Zinc plays important roles in growth and development, the immune response, neurological function and reproduction. Numerous aspects of cellular metabolism are zinc-dependent.

MECHANISM OF ACTION :

Alpha Lipoic Acid (ALA) inhibits the nerve damage caused by free radicals due to increased oxidative stress. Alpha Lipoic Acid improves nerve blood flow and increases sensory conduction. Chromium; it has been found to activate Insulin Receptor Kinase activity upto 7 fold. This activation may lead to increased insulin sensitivity, increases number of Insulin receptors and facilitates the attachment of Insulin of these sites. Zinc, nearly 100 different enzymes depend on zinc for their ability to catalyze vital chemical reactions.  

RECOMMENDED USES:

As a dietary supplement, Diamaxin can be used to; prevent complications associated with Diabetes like; Diabetic Neuropathy / Nephropathy / Retinopathy
Adult: Take One to two capsules daily or as prescribed by physician.

DRUG INTERACTIONS:

No established drug interaction.

ADVERSE EFFECTS:

Good tolerance profile without any adverse effect.

CONTRAINDICATION:

No independent and relative contraindication.

STORAGE: